Hepatocellular carcinoma (HCC) occurs in people with an underlying liver disease of either viral or toxic origin. It is usually preceded by cirrhosis. In the Czech Republic alcoholic liver disease is the major etiological factor. Tumor microenvironment is composed of myeloid (innate immunity) and lymphoid (adaptive immunity) lineages. Infiltrating immune cells can function to control tumor growth or to help create an immunosuppressive environment in which the tumor can thrive. The long suspected role for immune surveillance in human cancer has gained strong experimental support in the past decade. The concepts of ‘hot’ or ‘cold’ tumors refer to signs of inflammation (hot) when the tumor has already been infiltrated by T cells, which usually correlates with a response to immunotherapy. Even more gratifying, these scientific breakthroughs have also benefited clinical oncology in the context of diagnostics, prognostication, drug development and therapy.
Students for the following Ph.D. study topics are sought in the doctoral study programme:
T-cells as main actors in anti-tumor immunity
The long-suspected role of the importance of immunity in cancer has gained strong experimental support in the past decade. Infiltrating immune cells can function to control tumor growth or to help create an immunosuppressive environment in which the tumor can thrive. Immune surveillance by T-cells in human cancers is one of the key mechanisms of anti-cancer immunity.
Department of Hemato-Oncology, University Hospital Pilsen and Biomedical Center, Faculty of Medicine in Pilsen presents on May 3, 2018 from 13:00 at Seminar room (SO 01. 2.21), Biomedical Center, alej Svobody 1655/76, Plzeň 323 00 lectures from leading scientist from Imperial College London.
Recently, we published a review article entitled “A Double Edged Sword role of Interleukin-22 in Wound Healing and Tissue Regeneration” in prestigious journal ‘Frontiers in Immunology’. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). It is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology.
As part of Charles University’s constant efforts to develop and strengthen its research base, we are keen to recruit high-quality post-doctoral research fellows from abroad to work at top University or faculty centres and contribute to the University’s strong research profile. The goal of the International Post-Doc Research Fund is to attract promising post-docs who will carry out research within a specific field. Selection is carried out by the relevant research centre or department of the faculty (or other part of the University) responsible for the research. The Charles University Research Board assists in the management of the process. The International Post-Doc Research Fund was launched on 1 August 2011.
Laboratoř studia interakcí buněk s materiálem vypisuje Ph.D. pozice níže. V případě zájmu kontaktujte vedoucí laboratoře doc. RNDr. Marii Hubálek Kalbáčovou, Ph.D. (Tato e-mailová adresa je chráněna před spamboty. Pro její zobrazení musíte mít povolen Javascript.).
by Laura Abril-Parreño, Miriam Štiavnická, Olga García-Álvarez
Laboratory of Reproductive Medicine
Thursday 9rd March, 1:00 p.m. (no longer than 20 min. including discussion)
Přednáška profesora Kari Hemminki 1. 12. 2016 v 15:00 v Biomedicínském centru.
by Jan NEVORAL, Miriam ŠTIAVNICKÁ, Jiří MORAVEC
14. 11. 2016 at 2 p.m. in the Biomedical Center
Biomedical Center and Department of Surgery, Faculty of Medicine in Pilsen and University Hospital Pilsen, Charles University in Prague Pilsen, Czech Republic organize International Seminar on Liver Regeneration and Computational Modelling of Hepatobiliary Surgeries on 26–27 May 2016.
