Hepatocellular carcinoma (HCC) occurs in people with an underlying liver disease of either viral or toxic origin. It is usually preceded by cirrhosis. In the Czech Republic alcoholic liver disease is the major etiological factor. Tumor microenvironment is composed of myeloid (innate immunity) and lymphoid (adaptive immunity) lineages. Infiltrating immune cells can function to control tumor growth or to help create an immunosuppressive environment in which the tumor can thrive. The long suspected role for immune surveillance in human cancer has gained strong experimental support in the past decade. The concepts of ‘hot’ or ‘cold’ tumors refer to signs of inflammation (hot) when the tumor has already been infiltrated by T cells, which usually correlates with a response to immunotherapy. Even more gratifying, these scientific breakthroughs have also benefited clinical oncology in the context of diagnostics, prognostication, drug development and therapy.
Students for the following Ph.D. study topics are sought in the doctoral study programme:
T-cells as main actors in anti-tumor immunity
The long-suspected role of the importance of immunity in cancer has gained strong experimental support in the past decade. Infiltrating immune cells can function to control tumor growth or to help create an immunosuppressive environment in which the tumor can thrive. Immune surveillance by T-cells in human cancers is one of the key mechanisms of anti-cancer immunity.
The Chaperon ERA Research Club invites you to participate in our Nerd Art Prize contest by sending us your best scientific photo or picture!
Department of Hemato-Oncology, University Hospital Pilsen and Biomedical Center, Faculty of Medicine in Pilsen presents on May 3, 2018 from 13:00 at Seminar room (SO 01. 2.21), Biomedical Center, alej Svobody 1655/76, Plzeň 323 00 lectures from leading scientist from Imperial College London.
Recently, we published a review article entitled “A Double Edged Sword role of Interleukin-22 in Wound Healing and Tissue Regeneration” in prestigious journal ‘Frontiers in Immunology’. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). It is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology.
CHROMOSOMAL ABERRATION IN HEALTHY PERSONS
Blood white cells of healthy individuals may contain non-recurrent, random chromosomal aberrations (CAs), which disappear with cell turnover as they provide no growth advantage. These include chromatid breaks, fragmented or missing parts of chromosomes and fusions resulting in dicentric and ring chromosomes. These nonspecific CAs have been used in monitoring of occupational populations exposed to potential carcinogenic chemicals and radiation.
Familial occurrence of oropharyngeal and other HPV-associated cancers (OPC)
Prof. Kari Hemminki (European Research Area Chair of Translational Oncology) will provide presentation associate with investigation on Familial occurrence of oropharyngeal and other HPV-associated cancers (OPC) at section Head & Neck Forum – Epidemiology and Screening“ of the EUROGIN meeting.
As part of Charles University’s constant efforts to develop and strengthen its research base, we are keen to recruit high-quality post-doctoral research fellows from abroad to work at top University or faculty centres and contribute to the University’s strong research profile. The goal of the International Post-Doc Research Fund is to attract promising post-docs who will carry out research within a specific field. Selection is carried out by the relevant research centre or department of the faculty (or other part of the University) responsible for the research. The Charles University Research Board assists in the management of the process. The International Post-Doc Research Fund was launched on 1 August 2011.
Laboratoř studia interakcí buněk s materiálem vypisuje Ph.D. pozice níže. V případě zájmu kontaktujte vedoucí laboratoře doc. RNDr. Marii Hubálek Kalbáčovou, Ph.D. (Tato e-mailová adresa je chráněna před spamboty. Pro její zobrazení musíte mít povolen Javascript.).
by Laura Abril-Parreño, Miriam Štiavnická, Olga García-Álvarez
Laboratory of Reproductive Medicine
Thursday 9rd March, 1:00 p.m. (no longer than 20 min. including discussion)
