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Article by the Laboratory of Cancer Treatment and Tissue Regeneration published in Nature Communications

The team of the Laboratory of Cancer Treatment and Tissue Regeneration together with the research team from ETH Zürich led by prof. Inge Hermann published the article Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment in the journal Nature Communications (IF 14.92, Q1).

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Pharmacogenomics Laboratory publication "The position of the longest intron is related to biological functions in some human genes"

At the beginning of the new year, a bioinformatics article is published in the journal Frontiers in Genetics (Q1 in the Genetics & Heredity category) for the employees of the BC Pharmacogenomics Laboratory and the LFP Institute of Biology. The work, conceived as a pilot study, more closely characterizes the location of the longest intron within the sequence of human protein-coding genes. The previously known general information that the longest intron in eukaryotic organisms is usually the first intron, or one of the introns at the beginning of the gene, is clarified. According to our work, there are approximately 60% of such genes in the human genome. The article also focuses on genes in which the longest intron is located only in the second or third third of the gene. Using gene set enrichment analysis, it was possible to prove that for some genes there is a significant relationship between the location of the longest intron and their biological function. Of the genes important for the study of carcinogenesis, such genes include, for example, genes for DNA repair. The work also suggests a possible influence of the position of the longest intron on the tissue-specific level of gene expression. The laboratory will continue to focus on this newly formulated topic and look for its more specific connection to other topics of clinical research taking place in the laboratory with a focus on precision oncology.

The article is freely available to other researchers at: Frontiers | The position of the longest intron is related to biological functions in some human genes (frontiersin.org)

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Chaperon Newsletter No. 01/2023

Dear Chaperon subscribers,

we have a new year and new information for you from the Chaperon project!

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International Day of Women and Girls in Science

On the occasion of the celebration of the International Day of Women and Girls in Science, on 11th February, our university has decided to dedicate an article to selected foreign women that are doing their research at our University. The article talks about reasons why they choose to do research in general and why at our University. The article can be found here.

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Ph.D. Positions in Cancer Research

Biomedical Center, Faculty of Medicine in Pilsen, Charles University, is seeking students for the following Ph.D. study topics in the doctoral study programme of Experimental Surgery:

 

- DNA damage and its repair in mitochondrial DNA, implications in cancer cell

  (Tutor: MUDr. Pavel Vodicka, CSc.)

- Telomere homeostasis in interaction with DNA damage response in solid carcinogenesis

  (Tutor: MUDr. Pavel Vodicka, CSc.)

- Genomic/chromosomal instability in relation to microenvironment in colorectal cancer

  (Tutor: MUDr. Ludmila Vidckova, CSc.)

- Modelling of vessel tree in liver based on multi-domain CT scans

  (Tutor: Ing. Miroslav Jirik, Ph.D.)

- Differences in miRNA profile between colorectal cancer and colorectal cancer liver metastasis

  (Tutor: Mgr. Filip Ambrozkiewicz, Ph.D.)

- Explaining transition from nonmetastatic stage II to metastatic stages III and IV colon cancer through assessment of tumor microenvironment

  (Tutor: Andriy Trailin, M.D., DSc.)

- Immune cell landscape in primary and metastatic colorectal cancer

  (Tutor: Andriy Trailin, M.D., DSc.)

- Assessment of pharmacogenomics in breast cancer using multiomics methods

  (Tutor: Mgr. Viktor Hlavac. Ph.D.)

- Analysis of non-coding RNA as potential biomarkers in patients with solid tumors

  (Tutor: Mgr. Karolina Seborova, Ph.D.)

- Identification of prognostic and predictive molecular biomarkers of solid tumors at the level of DNA, RNA and in the form of circulating tumor DNA

  (Tutor: RNDr. Mgr. Radka Vaclavikova, Ph.D.)

- New therapeutic regimens and molecular basis of their action in experimental models of solid tumors

  (Tutor: RNDr. Mgr. Radka Vaclavikova, Ph.D.)

- Assisted recellularization of porcine liver scaffolds: Role of acoustic waves in tissue engineering

  (Tutor: RNDr. Vladimira Moulisova, Ph.D.)

- Decellularized porcine vessels as grafts with a great potential

  (Tutor: RNDr. Vladimira Moulisova, Ph.D.)

Application deadline: April 30, 2023

Contact: Barbora Stachová | This email address is being protected from spambots. You need JavaScript enabled to view it. |Tel: +420 377 593 467 | Department of Science and Research | Charles University, Faculty of Medicine in Pilsen

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Interview with scientist Monika Holubová

University magazine Universitas presents an interview with two scientists - Monika Holubová (Laboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University) a Lucie Houdová (NTIS, Faculty of Applied Science, University of West Bohemia) about the method of single cell analysis, which became the main topic of the summer school called Summer School of Single Cell. The first year took place in 2020, the second in 2022, and the next one is planned again in a two-year interval, i.e. in the summer of 2024.

In the article, you will read how the summer school came about, its goal is, and what makes the analysis of individual cells actually ground breaking.

You can find the article (in Czech) here.

MG 7368 2-1190x595-4185625594

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The Chaperon project invites you to a student event "Scientific Blind Dates"

Time and place: 22nd of March, 2023, 3:00 p.m., Seminar Room, Biomedical Center, Faculty of Medicine in Pilsen, the Charles University

The event is geared towards PhD students as an opportunity to practice their scientific presentation skills in an informal setting, however anybody who wishes to join should feel welcome - with even less formal socializing after the event being anticipated.

You can register here.

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Chaperon Newsletter No. 02/2023

Dear Chaperon subscribers,

we have new information for you from the Chaperon project!

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Chaperon Newsletter No. 03/2023

Dear Chaperon subscribers,

we have new information for you from the Chaperon project!

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Spring Meeting of Cancer Researchers in Javorná

From May 12 to 14, 2023, a regular meeting of collaborating research teams from our medical faculty, as well as experts from the Institute of Experimental Medicine of the Czech Academy of Sciences, and from the National Institute of Public Health took place for the twelfth time.

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Publication “Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer”

Scientists from Laboratory of Pharmacogenomics and Laboratory of Cancer Treatment and Tissue Regeneration co-authored just published experimental paper in Microbiome (D1 in ford Microbiology) describing results of the eight year lasting collaboration with team of prof. Julian Marchesi from Imperial College in London and colleagues from other top laboratories in Great Britain and Ireland.

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Chaperon Newsletter No. 04/2023

Dear Chaperon subscribers,

we have new information for you from the Chaperon project!

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Chaperon Newsletter No. 05/2023

Dear Chaperon subscribers,

we have new information for you from the Chaperon project!

The New Town Hall in Prague hosted the CUCAP conference

The conference on Current Understanding of Colorectal and Pancreatic Cancer organized by Chaperon took place in Prague on May 29th and 30th, 2023. Continue reading here....

Spring Meeting of Cancer Researchers in Javorná

From May 12th to 14th, 2023, a regular meeting of collaborating research teams from our medical faculty, as well as experts from the Institute of Experimental Medicine of the Czech Academy of Science, and from the National Institute of Public Health took place for the twelfth time. This year, Prof. Dr. Inge Herrmann from the Swiss ETH Zurich accepted our invitation as well. Read more here...

The Review Paper “Theranostics Nanomedicine Applications for Colorectal Cancer and Metastasis: Recent Advances”

The team of Translational Cancer Genomics has recently published a review on "Nanomedicine Applications for Colorectal Cancer and Metastasis". Read more here...

 Prof. Hemminki awarded the best presenting authors in the 60th Student Scientific Conference

After 3 years of pandemic break, the 60th Student Scientific Conference finally took place on May 17. Continue reading here...

 The Chaperon ERA Research Club invites you to participate in our next Student Event “The use of Al in literature review”

Time and place: 14th of June, 3 pm, Seminar room 01.2.21 in Biomedical Center in Faculty of Medicine in Pilsen. More information here...

 Picture of the month – May

We would like to introduce the winners and participants of Nerd Art Prize 2022 as the picture of the month. For May it was a picture of a rare form of aragonite by Petr Jan Juračka. See more here...

ERA Chair Position for Excellent Research in Oncology

A project funded from the European Union's Horizon 2020 research and innovation programme under grant agreement No 856620.

Twitter account

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Smart sealants for early detection of anastomotic leakage, article published in Advanced Sicence

An article was published in Advanced Science (IF 17.521, Q1, Decile 1) this week that arises from the collaboration of our lab with the research team from ETH Zürich led by prof. Inge Herrmann.

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Latest findings from cancer research under a gothic roof: international conference brought researchers to the New Town Hall

Top scientists discussed the latest findings in colon and pancreatic cancer research at the international conference "Current Understanding of Colorectal and Pancreatic Cancers (CUCAP)" on 29 and 30 May 2023. The successful event was organized by the Faculty of Medicine in Pilsen of the Charles University in cooperation with the Institute of Experimental Medicine of the Czech Academy of Sciences.

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Contact

Charles University
Faculty of Medicine in Pilsen
Biomedical Center

alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

T: +420 377 593 810
E: This email address is being protected from spambots. You need JavaScript enabled to view it.

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