Three positions for PhD study in brain physiology and pathophysiology are open for applicants
Hippocampus - place cells - grid cells - prefrontal cortex - memory - calcium imaging - electrophysiology - eeg - neural networks
Positions formally start in Oct, but the funding is partially available since summer.
Each of them is covered with a stipend and project salary of ca 750 EUR/month after taxing.
Apply by 31. April 2018
It is advisable to contact dr. Jezek or dr. Blahna.
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Sleep activity in health and ilness
Supervisor: Karel Blahna , M.D., Ph.D.
Laboratory of Experimental Neurophysiology, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University
Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University
Annotation:
Sleep activity in health and ilness
The aim of the project is to understand in detail the mechanisms of processing information in sleep across brain memory systems under physiological and pathological conditions. The memory track is gradually built and then transformed from temporary (hippocampus) into long-term storage (cortex). This process of transmission of information requires exact timing of the activity of the involved brain structures that occurs when the organism is at rest or in sleep. The theme of the project will be the study of these mechanisms in physiological conditions and in human disease models. Methods of recording unit activity and eeg in laboratory rodents will be used.
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Memory processing and brain rhythms
Supervisor: Karel Ježek, M.D., Ph.D.
Laboratory of Experimental Neurophysiology, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University
Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University
Annotation:
Spatial memory in mammals is processed in neural networks of hippocampo-neocortical brain circuitry. As these networks intensively communicate, their activity must be precisely synchronized. The goal of this project is to characterize various rhythms present in the hippocampal system and to explore their role in spatial memory processing by electrophysiology techniques in laboratory animals.
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Brain activity, cellular imaging and memory
Supervisor: Karel Ježek, M.D., Ph.D.
Laboratory of Experimental Neurophysiology, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University
Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University
Annotation:
The goal of the project is to better understand information processing in brain memory systems. Large scale neural networks build step by step complex representations of the surrounding world, stored in the patterns of neural activity. Eventually, these memory engrams get activated by poorly understood retrieval process. The main theme of the program will be a study of neural representations performed both by classical in vivo techniques of multiunit electrophysiology and by recent methods of cellular Calcium imaging in laboratory rodents while performing in cognitive tests. The work will focus on network memory state-changes as a model of memory retrieval in physiology and under the states simulating various human neuropathologies.