Laboratory of Pharmacogenomics publication “Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy”

Scientists from Laboratory of Pharmacogenomics just published experimental paper in Life Science Alliance (Q1 in ford Biology). The study provides so far most comprehensive comparison of genetic alterations within the coding part of the genome of patients stratified by their platinum resistance status, tumor subtype, and survival.

Among other findings, distinct mutational signatures, for example, SBS6, and overall mutational load, somatic mutations in PABPC1, PABPC3, and TFAM co-segregated with the resistance status, high-grade serous carcinoma subtype, or overall survival of patients. Further follow-up studies focused on utilizing the observed associations in precision oncology are now in progress in the lab.

Link to the article:



Charles University
Faculty of Medicine in Pilsen
Biomedical Center

alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

T: +420 377 593 810
E: This email address is being protected from spambots. You need JavaScript enabled to view it.


Log in to your account or Create an account