Two small steps ahead in mapping individual susceptibility towards colorectal cancer

We would like to introduce two major works of co-authors of Pavel Vodička, Ludmila Vodičková and Veronika Vymetálková from the team of the Laboratory of Cancer Treatment and Tissue Regeneration. These two publications published in Q1 journal Gastroenterology (IF 19.809) are based on the research they were working on.

Murphy N.; Carreras-Torres R.; …; Vodička P.; Vodičková L.; Vymetálková V.: Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses.Gastroenterology. 2020 Apr;158(5):1274-1286.e12. doi: 10.1053/j.gastro.2019.12.012. IF: 19.809.


In this analysis of blood samples from almost 400 000 participants from the UK Biobank, they found the association between circulating level of Insulin-like growth factor 1 (IGF1) and colorectal cancer. They used genetic data from 52 865 cases with colorectal cancer. Higher level of IGF1, determined by genetic factors, was associated with icreased risk of colorectal cancer. Further studies are needed to determine how this signaling pathway might contribute to colorectal carcinogenesis.


Archambault A. N; Su Yu-Ru; Jeon J.; Thomas M.; Lin Yi; Conti D. V; ...; Vodičková L.; Vodička P....: Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer. Gastroenterology. 2020 Apr;158(5):1274-1286.e12. doi: 10.1053/j.gastro.2019.12.012.



In this analysis of associations with colorectal carcinoma (CRC) per standard deviation of polygenic risks score (PRS), they found the cumulative burden of CRC-associated common genetic variants to more strongly associate with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive examinations.

Congratulation to authors!

Václav Liška, M.D., Ph.D.


Charles University
Faculty of Medicine in Pilsen
Biomedical Center

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