Murphy N.; Carreras-Torres R.; …; Vodička P.; Vodičková L.; Vymetálková V.: Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses.Gastroenterology. 2020 Apr;158(5):1274-1286.e12. doi: 10.1053/j.gastro.2019.12.012. IF: 19.809.
In this analysis of blood samples from almost 400 000 participants from the UK Biobank, they found the association between circulating level of Insulin-like growth factor 1 (IGF1) and colorectal cancer. They used genetic data from 52 865 cases with colorectal cancer. Higher level of IGF1, determined by genetic factors, was associated with icreased risk of colorectal cancer. Further studies are needed to determine how this signaling pathway might contribute to colorectal carcinogenesis.
Archambault A. N; Su Yu-Ru; Jeon J.; Thomas M.; Lin Yi; Conti D. V; ...; Vodičková L.; Vodička P....: Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer. Gastroenterology. 2020 Apr;158(5):1274-1286.e12. doi: 10.1053/j.gastro.2019.12.012.
In this analysis of associations with colorectal carcinoma (CRC) per standard deviation of polygenic risks score (PRS), they found the cumulative burden of CRC-associated common genetic variants to more strongly associate with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive examinations.
Congratulation to authors!
