Laboratory of Cancer Treatment and Tissue Regeneration

About us

Our laboratory is concerned on study of regeneration of parenchymal organs in a relation to supposed extensive surgical procedures. Our goal is to experimentally verify all possibilities that can be used for the treatment of patients with cancers, especially liver malignancies. We are checking the significance of stimulated regeneration of the future liver remnant damaged for example by oncologic experimental treatment in large animals (established are experimental model of steatohepatitis associated with chemotherapy, model of toxic alcoholic liver disease, model of biliary cirrhosis etc.)

We also develop special software models and advanced imaging analysis to predict regeneration capacity of the liver parenchyma and diagnose focal and diffuse liver diseases.

There is also included imaging of a portal system microcirculation as well. Finally we use our findings to spread our clinical treatment possibilities. We closely cooperate with the Labs of Pharmacogenomics, Tumor Biology and Quantitative Histology and we try to transfer their research results to our clinical requirements and applications.

Our team is fully instrumentally equipped to perform experiments in large animals. We also have skilled team of experts (including surgeons, anaesthesiologists, radiologists, biomechanics or experts of theoretical and laboratory fields) available to perform broad spectrum of surgical procedures. This team participates every year in preparing of the Summer School of Experimental Surgery annually held by our medical school.

Long-term aims

regeneration of liver parenchyma and liver surgery
portal micro- and macrocirculation
reconstruction of portal system
surgical and oncological treatment of malignancies
immune system behaviour during progression of tumour disease

Releated Research themes

Contact

Biomedical Center
alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

Members

Prof. Václav Liška, M.D., Ph.D. – Research Group Leader
Prof. Vladislav Třeška, M.D., Ph.D.
Kristýna Bajcurová, M.D., Ph.D.
Jan Brůha, M.D., Ph.D.
Ondřej Brzoň, B.Sc.
Lenka Červenková, D.V.M.
Lada Eberlová, M.D., Ph.D.
Assoc. Prof. Ondřej Fiala, M.D., Ph.D.
Zuzana Fišerová
Petr Hošek, Ph.D.
Miroslav Jiřík, M.Sc., Ph.D.,
Marie Karlíková, M.Sc., Ph.D.
Eva Korčáková, M.D., Ph.D.
Lenka Kuberková
Maria Stefania Massaro, M.Sc.
Assoc. Prof. Hynek Mírka, M.D., Ph.D.
Vladimíra Moulisová, M.Sc., Ph.D.
Alena Opattova, M.Sc., Ph.D.
Richard Pálek, M.D., Ph.D.
Robert Polák, M.D.
Sima Šarčevič, M.D.
Jáchym Rosendorf, M.D., Ph.D.
Roshan Kumar Singh, M.Sc.
Jiří Škorpil, M.D., Ph.D.
Nela Štorková, M.Sc., Ph.D.
Pavel Vodička, M.D., Ph.D.
Ludmila Vodičková, M.D., Ph.D.
Ondřej Vyčítal, M.D., Ph.D
Veronika Vymetálková, M.Sc., Ph.D.
Marek Brousil
Lucie Kepková
Pavel Krystl
Jan Ševčík
Tomáš Polenda
Táňa Drhovská
Lukáš Plzák
Daniel Vydra
Martin Strouhal
Dmytro Kvach