Three positions for PhD study in brain physiology and pathophysiology are open for applicants
Hippocampus - place cells - grid cells - prefrontal cortex - memory - calcium imaging - electrophysiology - eeg - neural networks
Positions formally start in Oct, but the funding is partially available since summer.
Each of them is covered with a stipend and project salary of ca 750 EUR/month after taxing.
Apply by 31. April 2018
It is advisable to contact dr. Jezek or dr. Blahna.
This email address is being protected from spambots. You need JavaScript enabled to view it.
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Sleep activity in health and ilness
Supervisor: Karel Blahna , M.D., Ph.D.
Laboratory of Experimental Neurophysiology, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University
Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University
Annotation:
Sleep activity in health and ilness
The aim of the project is to understand in detail the mechanisms of processing information in sleep across brain memory systems under physiological and pathological conditions. The memory track is gradually built and then transformed from temporary (hippocampus) into long-term storage (cortex). This process of transmission of information requires exact timing of the activity of the involved brain structures that occurs when the organism is at rest or in sleep. The theme of the project will be the study of these mechanisms in physiological conditions and in human disease models. Methods of recording unit activity and eeg in laboratory rodents will be used.
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Memory processing and brain rhythms
Supervisor: Karel Ježek, M.D., Ph.D.
Laboratory of Experimental Neurophysiology, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University
Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University
Annotation:
Spatial memory in mammals is processed in neural networks of hippocampo-neocortical brain circuitry. As these networks intensively communicate, their activity must be precisely synchronized. The goal of this project is to characterize various rhythms present in the hippocampal system and to explore their role in spatial memory processing by electrophysiology techniques in laboratory animals.
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Brain activity, cellular imaging and memory
Supervisor: Karel Ježek, M.D., Ph.D.
Laboratory of Experimental Neurophysiology, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University
Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University
Annotation:
The goal of the project is to better understand information processing in brain memory systems. Large scale neural networks build step by step complex representations of the surrounding world, stored in the patterns of neural activity. Eventually, these memory engrams get activated by poorly understood retrieval process. The main theme of the program will be a study of neural representations performed both by classical in vivo techniques of multiunit electrophysiology and by recent methods of cellular Calcium imaging in laboratory rodents while performing in cognitive tests. The work will focus on network memory state-changes as a model of memory retrieval in physiology and under the states simulating various human neuropathologies.
How does the brain process information, how is the information stored in form of memory traces and then recalled as memories? How are the movement and memories related? What happens in the brain while dreaming? These and other topics were discussed with researchers from the Biomedical Center during the 20th year of the Brain Awareness Week from 12th to 16th March.
Brain Awareness Week is a unique cycle of lectures on the latest discoveries and trends in in brain research and neuroscience. The Czech event is a part of a worldwide awareness campaign on the successes and benefits of brain research. The Pilsen Medical Faculty has joined this nationwide event for the second time this year.
On the premises of the Study and Science Library, interactive lessons of “Maps In Our Mind” (in English and Spanish), intended for schools, took place during the mornings. Three afternoons of the week were devoted to lectures for the public, as well as a projection of a documentary movie “Vergiss mein nicht” on the subject of Alzheimer's disease. In total, about 150 people took part in the Brain Awareness Week in Pilsen.
Dr. Karel Blahna was awarded 8 mil. CZK grant to study cognitive processing in hippocampus and prefrontal cortex during sleep.
´SLEEP DYNAMICS OF BRAIN NEURAL NETWORKS IN HEALTH AND DISEASE´
A great completion in covering our scietific field across different brain states - we can now study both awake and sleep memory processing in the brain.
The funding brings new postdoc and PhD positions.
More info on This email address is being protected from spambots. You need JavaScript enabled to view it.
Congrats!
on Tue 28th July at cca 10.30, Sophie Rosay and Zeynep Kaya from Alessandro Treves at SISSA, Trieste, are going to present their projects about neurogenesis in Dentate Gyrus and network state transitions.
Check out Ikeda's installation in Pilsen theatre (ending Aug 11th) and let your brain to be driven by light and sound manipulations in the space.
It nicely illustrates our experimental paradigms in much more intensive way. Great to get ieas & intuition for designing new experiments.
if interested in neuro, join any of these online courses for free!
https://www.coursera.org/course/compneuro
After many months of negotiations we've got a new transgenic rat model of Alzheimer disease called Tg F-344 AD.
This model is unique and promissing as it combines two human transgenes (for amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9)). Introduced in 2013, they manifest age-dependent cerebral amyloidosis that precedes tauopathy, gliosis, apoptotic loss of neurons in the cerebral cortex and hippocampus, and cognitive disturbance.
Our plan is to study pathophysiology of AD onset in hippocampal and neocortical neural networks.
The incoming animals are to set the core of a new breeding colony. Hope they did not forget how to breed...
