Briefly

Mitochondria are inherited down to the maternal lineage and, therefore, oocyte mitochondrial health is essential for the fitness of offspring. We hypothesize that the transcription of mitochondrial (mt) DNA is essential for the renewal of maternal mitochondria and the elimination of mtDNA mutations. The model of conditional knock-out mouse will be used for the study of TFAM, transcriptional factor A, mitochondrial. Oocytes and early embryos will be produced and analyzed via immunostaining and mtDNA sequencing. The knowledge will explain causes of infertility associated with advanced maternal age, and improve assisted reproductive techniques.

Requirements

• MSc. In life sciences
• Basic laboratory experience
• Entusiasm and good spirit

What can you expect?

• International team
• High-tech lab equipment
• Traveling and fellowships

Used techniques