A Double Edged Sword role of Interleukin-22 in Wound Healing and Tissue Regeneration

Recently, we published a review article entitled “A Double Edged Sword role of Interleukin-22 in Wound Healing and Tissue Regeneration” in prestigious journal ‘Frontiers in Immunology’. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). It is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology.

The Frontiers in Immunology journal is 5th most cited Immunology journal in the world and ranks in the top Impact Factor and Cite Score percentiles with Impact factor: 5.5. Cite score, 5.62. In this article we reviewed the detailed role of Interleukin -22 in inflammation, mucous production, protective role against pathogens, wound healing and tissue regeneration. Article describes the pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. Overall, article, summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.

Sobia Manzoor joined research group (Cancer treatment and Tissue Regeneration labs) of Professor Vaclav Liska at Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Prague, Czech Republic as a senior postdoctoral researcher in December 2019. In her postdoctoral research, she is investigating the role of IL22 in persuading, development, and metastasis of hepatocellular carcinoma. Published article is a part of her postdoctoral research project „Regeneration of liver parenchyma and its relation to carcinogenesis of primary liver tumors“.


Sobia Manzoor, Ph.D.

doc. MUDr. Václav Liška, Ph.D.


Charles University
Faculty of Medicine in Pilsen
Biomedical Center

alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

T: +420 377 593 810
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