The success of the team of the Laboratory of Cancer Treatment and Tissue Regeneration

The Tumor Therapy and Tissue Regeneration team of the Biomedical Center of the Faculty of Medicine, Charles University in Pilsen has achieved great success by publishing a comprehensive review summarizing the treatment options for colorectal cancer and the mechanisms of action of 5-Fluorouracil at the molecular level, including anabolic and catabolic pathways in Pharmacology & Therapeutics journal.

The article covers all known molecular mechanisms that underlie chemoresistance in patients with colorectal cancer. It also targets various developed 5-Fluorouracil pro-drugs to increase the amount of circulating 5-Fluorouracil and to reduce its toxicity. The article also proposes future directions of personalized therapy in colorectal cancer according to the latest published results. See more.

Ing. Veronika Vymetálková, Ph.D.



Charles University
Faculty of Medicine in Pilsen
Biomedical Center

alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

T: +420 377 593 810
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