About us
The research of the group is mainly focused on interactions between human cells (osteoblastic cell line, primary fibroblasts, mesenchymal stem cells, etc.) and surfaces or nanoparticles prepared from different biocompatible materials with controlled properties.
Materials studied by our research group are of different chemistry – carbon (nanocrystalline diamond and graphene), titanium (nanostructured and ultra fine titanium), biodegradable nanocomposites (based on aliphatic polyester nanofibers with collagen, calcium phosphate nanoparticles and sodium hyaluronan), silicon (silicon nanoparticles doped with boron and phosphorus) and hyaluronic acid (hydrogels, complexes with surfactants). Used materials are tested as solid surfaces for interaction with adherent cells (implantology, sensing, etc.) and as nanoparticles for sensing, imaging and drug delivery.
The aim of projects concerned on solid surfaces is to describe the influence of the material properties on the cell survival, adhesion, growth and differentiation. Knowledge gained from our research can be utilized in fabrication of coatings for bone implants improving the healing process and also, thanks to controllable electrical conductivity of these materials, in construction of bio-electronic devices and biosensors.
The aim of projects concerned on nanoparticles is to study the influence of nanodiamond, silicon nanoparticles and hyaluronan complexes on human cells regarding their utilization as markers in fluorescence microscopy and as the vehicles for drug delivery. Thus their biocompatibility, their entry and release of the cell, cellular localization, specific cell targeting are deeply studied.
Releated Research themes
Contact
Biomedical Center
alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí
Members
- Assoc. Prof. Marie Hubálek Kalbáčová, Ph.D. – Research Group Leader
- Lucie Ostrovská, M.Sc.
- Pavla Sauerová, M.Sc.
- Lucie Vištejnová, Ph.D., M.Sc.
- Iva Machová, Ph.D., M.Sc.
- Tereza Bělinová, B.Sc.